Nytol One-A-Night 50mg Tablets
Pack of 20 tablets · Film-coated tablets
A pharmacy-only sedating antihistamine for the short-term relief of temporary sleeplessness in adults.
Official medicine information
View the SmPC and Patient Information Leaflet on emc
electronic Medicines Compendium — the authoritative source for UK licensed medicine information.
Active ingredient
Diphenhydramine hydrochloride
Strength
50mg
Form
Film-coated tablets
Pack size
Pack of 20 tablets
How it works
Diphenhydramine is a first-generation antihistamine with sedative properties. It blocks histamine in the brain to help promote sleep.
How to take
Adults aged 16 and over: take one tablet 20 minutes before bedtime. Do not take for more than two weeks without speaking to a pharmacist.
Possible side effects
- Daytime drowsiness or 'hangover' feeling
- Dry mouth
- Blurred vision
- Constipation
Important warnings
- Do not drive or operate machinery if you feel drowsy the next day.
- Avoid alcohol while taking this medicine.
- Not suitable in glaucoma, prostate enlargement, or severe liver disease.
- Speak to the pharmacist if pregnant, breastfeeding or taking other medicines.
Storage
Store below 25°C in the original packaging. Keep out of the sight and reach of children.
Important
This information is provided for general guidance only and is not a substitute for professional clinical advice. Treatment is only supplied following a consultation, suitability checks and pharmacist review. If this medicine is not suitable for you, our pharmacist will discuss alternatives.
Always read the patient information leaflet supplied with your medicine. If you have a medical emergency, call 999 immediately.
Suspected side effects can be reported via the MHRA Yellow Card scheme. Reporting helps make medicines safer for everyone.
Last reviewed by our Superintendent Pharmacist: Jane Doe MRPharmS, April 2026.
Take the next step toward better sleep, less stress, and better pain support.
Browse our treatments — you can request a confidential, pharmacy-led consultation.
Treatment available where clinically appropriate.